What is Saccharin?

What is Saccharin?

What is Saccharin?

Saccharin, also called saccharine or benzosulfimide, or used in saccharin sodium or saccharin calcium forms, is a non-nutritive artificial sweetener. Saccharin is a benzoic sulfimide that is about 500 times sweeter than sucrose, but has a bitter or metallic aftertaste, especially at high concentrations. It is used to sweeten products, such as drinks, candies, baked goods, tobacco products, excipients, and for masking the bitter taste of some medicines. It appears as white crystals and is odorless.

Saccharin is one of the most thoroughly tested food ingredients in the world. Extensive research has affirmed the sweetener’s safety time and again. The evidence in support of saccharin’s safety includes more than 30 human studies, one of which was conducted by the National Cancer Institute and involved over 9,000 individuals.

How is saccharin different from sugar?

Both saccharin and sugar provide sweet taste. However, saccharin is 200–700 times sweeter than sugar, so only a tiny amount is needed to provide the same level of sweetness as sugar. In addition, saccharin is calorie-free, while sugar provides four calories per gram. When we consume sugar, our body breaks it down into glucose and fructose, uses what it needs for energy, and stores the rest in various forms for future use. In contrast, when we consume saccharin, our bodies don’t break it down or use it for energy. Instead, saccharin passes through the body unchanged, providing no calories in the process.

Is saccharin safe?

Yes, saccharin is safe to consume. It’s one of eight low and no-calorie sweeteners permitted by the U.S. Food and Drug Administration (FDA) for use in the U.S. food supply.

In addition to the FDA, leading global health authorities such as the European Commission’s Scientific Committee on Food (SCF, now known as the European Food Safety Authority) and the Joint FAO/WHO Expert Committee on Food Additives (JECFA) have concluded that saccharin is safe for human consumption. The safety of saccharin has also been confirmed by Japan’s Ministry of Health, Labour and Welfare; Food Standards Australia New Zealand; and Health Canada. Based on the conclusions of worldwide government and health organizations, saccharin is permitted for use in more than 100 countries.

Many of these approvals of saccharin came after concerns were raised in the 1970s about the safety of consuming saccharin. Initial studies at the time suggested that saccharin was linked to bladder cancer in male rats and might similarly affect humans. Through subsequent research, however, it was determined that saccharin does not cause cancer in humans, because the biological mechanisms responsible for the development of cancer from saccharin consumption are specific to rats and do not apply to human bodies.

 Did you know?

Did you know that there is a purpose behind the different colors of common tabletop sweeteners? For those in the know, differently colored packets make it easier to quickly identify and choose your preferred type of sweetener. You may be most familiar with the color of sugar packets: White packets contain table sugar, and brown packets contain raw sugar. But low- and no-calorie sweetener packets have a consistent color code as well: Pink packets contain saccharin, blue packets contain aspartame, green packets contain stevia sweeteners, and yellow packets contain sucralose.

The effects of water and (NNS) beverages on weight loss

The effects of water and (NNS) beverages on weight loss

The effects of water and non-nutritive sweetened beverages on weight loss during a 12-week weight loss treatment program. The study used an equivalence design with non-nutritive sweetened beverages and water as the main factor. Acute and medium-term intervention studies suggest that non-nutritive sweeteners (NNS) are beneficial for weight loss. The trial will assess the efficacy of NNS beverages compared to water during a behavioral weight loss and maintenance programme.


To compare the efficacy of non-nutritive sweetened beverages (NNS) or water for weight loss during a 12-week behavioral weight loss treatment program.


An equivalence trial design with water or NNS beverages as the main factor in a prospective randomized trial among 303 men and women was employed. All participants participated in a behavioral weight loss treatment program. The results of the weight loss phase (12 weeks) of an ongoing trial (1 year) that is also evaluating the effects of these two treatments on weight loss maintenance were reported


The two treatments were not equivalent with the NNS beverage treatment group losing significantly more weight compared to the water group (5.95 kg versus 4.09 kg; P < 0.0001) after 12 weeks. Participants in the NNS beverage group reported significantly greater reductions in subjective feelings of hunger than those in the water group during 12 weeks.


These results show that water is not superior to NNS beverages for weight lo NNS beverages were superior for weight loss and weight maintenance in a population consisting of regular users of NNS beverages who either maintained or discontinued consumption of these beverages and consumed water during a structured weight loss program. These results suggest that NNS beverages can be an effective tool for weight loss and maintenance within the context of a weight management programs during a comprehensive behavioral weight loss program.


John C Peters ,  Holly R WyattGary D Foster



(Avocado)DOI: 10.1177/1947603514554992. Blaine A. Christiansen, Simrit Bhatti, Ramin Goudarzi, and Shahin .Emami (2015)


Osteoarthritis (OA) is a chronic synovial joint disease. .Particularly That characterized by two main features

Progressive Damage of Articular .Cartilage

Among the progressive damage of articular cartilage, specifically we can mention bone regeneration, new bone formation, synovial inflammation, fibrosis of ligaments, tendons and meniscal capsules

In any case, all joints may be affected, the most common being the knees, hands, and hips, .Compounds Osteoarthritis (OA)

Besides, it was reported that it can improve the mood and quality life of postmenopausal women .thus reducing menopause-related symptoms

Progressive damage of articular cartilage is a term used to describe the gradual deterioration and breakdown of the smooth, protective tissue that covers the ends of bones in a joint. also This type of damage is often associated with conditions such as osteoarthritis, a degenerative joint disease that is characterized by the breakdown of cartilage over time.

Compounds Osteoarthritis (OA)

Avocado and soybean unsaponifiables

Are natural vegetable extracts made from avocado and soybean oils, consisting of the leftover fraction (1%). also ASU is composed of one-third avocado and two thirds soybean .unsaponifiables (A1S2U)

The major components of ASU

Phytosterols β-sitosterol, campestral, and stigmasterol all of a sudden T is rapidly incorporated into cells. so, the sterol contents of ASU preparations are the primary. Contributors to biological activity in particular chondrocytes. Accordingly, the association of all extracts which constitute ASU exerts more powerful synergistic effects, unquestionably different from that exercised by each of. the individual components.

Avocado and soybean unsaponifiable (ASU) is a mixture of compounds derived from avocado and soybean oils. additionally, the major components of ASU include various bioactive molecules that contribute to its potential health benefits, particularly in supporting joint health and managing conditions like osteoarthritis.

Coenzyme Q10 as a migraine preventive

Coenzyme Q10 as a migraine preventive

coenzyme Q10 as a migraine preventive

The objective was to assess the efficacy of coenzyme Q10 as a preventive treatment for migraine headaches. Thirty-two patients (26 women, 6 men) with a history of episodic migraine with or without aura were treated with Q10 at a dose of 150 mg per day. Thirty-one of 32 patients completed the study; 61.3% of patients had a greater than 50% reduction in number of days with migraine headache. The average number of days with migraine during the baseline period was 7.34 and this decreased to 2.95 after 3 months of therapy, which was a statistically significant response (P < 0.0001).


Mean reduction in migraine frequency after 1 month of treatment was 13.1% and this increased to 55.3% by the end of 3 months. Mean migraine attack frequency was 4.85 during the baseline period and this decreased to 2.81 attacks by the end of the study period, which was a statistically significant response (P < 0.001). There were no side-effects noted with Q10. From this open label investigation Q10 appears to be a good migraine preventive. Placebo-controlled trials are now necessary to determine the true efficacy of  Q10 in migraine prevention.